Here are our 6 Best ASX Stocks for 2025 and why you should give them a look!

Here are our 6 Best ASX Stocks for 2025!

Opthea (ASX:OPT)

Its been a long wait, but 2025 will finally be the year Opthea (ASX:OPT) investors receive Phase 3 results. Opthea is an optometry biotech developing Sozinibercept – a drug fighting wet AMD. Wet AMD is the leading cause of blindness, impacting 3.5m people annually across the globe.

There are existing treatments, but they only inhibit VEGF-A, not VEGF-C and VEGF-D, but Opthea does. Even so, global sales of Lucentis and Eyelea were nearly US$8bn between them. Sozinibercept is intnded to be used in combination with them or other VEGF-A inhibitors, and has a more comprehensive effect than just the one treatment. Opthea reckons it has a US$15bn market based off the sales for all its competitors. And when it is approved, Sozinibercept could have up to 12-year market exclusivity.

The company is running 2 trials with nearly 1,000 each. Enrollment has been completed in both of them, and with a 52-week treatment period, results from the first trial are expected in the March quarter of 2025, while the second is due in the June quarter. The company is targeting a 5.7 letter change in BCVA from baseline at 24 weeks – essentially how many more letters can a patient read on that typical letter chart you read at your eye check ups.  

Boss Energy (ASX:BOE)

We will admit that whatever this company does, any potential re-rating could be subject to uranium prices stabilising from their retreat in 2024. Boss Energy has the Honeymoon project in South Australia, and has just re-started production.

Lying in South Australia, it has 52.4Mt at 0.062% uranium for 71.6Mlbs. The Measured category has 3.1Mt for 7.6Mlbs uranium. Boss anticipates a 10 year mine life with 2.5Mlb annual production over that time. And that’s before you account for further exploration at the project – it reckons there’s a 100Mlb exploration target. In FY25 alone, it anticipates 850k lbs. We are optimistic about uranium because we are optimistic about nuclear. Look no further than Peter Dutton’s plan or at tech giants to invest in nuclear-backed solutions for AI-related energy requirements.

Boss Energy has a market cap of over US$1.3bn, zero debt and $245m in cash and liquid assets. Its addition to the ASX 200 has raised its attention among institutional investors. The company has entered into binding sales agreements to sell 3.5Mlbs to major American an European power utilities over the next 8 years.

Xero (ASX:XRO)

At first glance, Xero (ASX:XRO) may appear expensive with a high PE multiple and having such a high market penetration (at first glance). But the company thinks it can double its size and is still underpenetrated in many markets, even its core segments.

The company believes the TAM (Total Addressable Market) is NZ$100bn and that is just the top 3 jobs its software is used for – Accounting, Payroll and Payments. Adjacent Tasks, including other tasks such as inventory, CRM and project management, could be another $39bn.

OFX (ASX:OFX)

This is a classic ‘buy the dip’ opportunity. As its name implies, OFX specialises in forex services for business. businesses that need forex services will need them regularly. Clients want competitive pricing, high standards of security, the ability to manage volatility risk of forex exposure and the ability to speak to a human being when things go wrong (not a chatbot) and OFX provides this enhanced service.

Customers pay a $15 fee if under A$10,000, but no fee if it’s above that amount. OFX also makes money by taking a forex spread on each acquisition – the difference between the rate quoted by OFX to its client and the cost for OFX to acquire the currency. Clients can be consumers or businesses and the reasons for transfers are endless, from transferring money between family members or purchasing a vintage car or villa in another country. These can be one-off transfers, regular transfers or in some instances OFX’s software is integrated into a business’ own software to make transfers seamless.

OFX can be bought as a bargain price because it withdrew its guidance for FY24 just 5 months after issuing it. Why? Later then anticipated shifts in the interest rate cycle saw a slower rebound in consumer confidence. Our thesis on OFX is simple – rate cuts eventuating will change that. Keep in mind that even for FY24, still expects NOI growth and a 28% EBITDA margin.

Spartan Resources (ASX:SPR)

At the end of last year, we thought De Grey (ASX:DEG) was set for good things, and we were right, with the company being bought by Northern Star (ASX:NST) for $5bn. So who’s next to be bought out? We reckon Spartan Resources.

Spartan is capped at over $1.7bn and is 19.9% owned by Ramelius. An obvious sign if ever it was one – because RMS cannot buy more without making a formal takeover offer. The stock recently raised over $200m in a capital raising to fund development of its Dalgaranga gold project in WA’s Murchison region and RMS chipped in.

Dalgaranga has 15.9Mt @ 5.61 g/t for 2.87Moz of gold. In just two years, Spartan has increased the ounces by 680% and the grace by 86%. This ASX gold stock, the 15th largest right now according to ListCorp, is headed by Simon Lawson, a former senior geologist at Northern Star. The key focus of the company is completing a Feasibility Study, infrastructure early works at a service level and underground development.

Dominos (ASX:DMP)

We’ve been bullish on this one for years, but our predictions on this company’s rebound have not eventuated. But we think the year ahead will different for Dominos (ASX:DMP). Why should you believe us this time? Because 2025 is already guaranteed to be different by virtue of having new leadership and having all but abandoned growth targets that were arguably unrealistic (not formally abandoning them but admitting the ‘7,100 stores by 2033’ was unlikely to be achieved). Keep in mind that it has a solid inroad into Australia, New Zealand and a number of European markets.

The company now wants to grow, not through store numbers, but by having drivers improve delivery times and issue more pizzas. Of course there is reason to deliver faster, because product quality suffers. It has also taken steps to fix unprofitable individual franchises. And it is focusing more on Europe rather than Asia.

In Germany and France, the company claims that 70% of the country remains uncovered and there is more room for growth. And it is claiming progress has been made in winning customers back since launching automated re-engagement campaigns. This can be accepted, along with assertions that Europeans do consume pizza.

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